Source: Examine.com — Alpha-GPC — 300–600 mg for cognition/power output; 400 mg is a common single dose.
400 mg is the performance dose; cognitive-decline trials use 1,200 mg/day split 3×.
A highly bioavailable choline compound that crosses into the brain and fuels acetylcholine.
Delivers choline for acetylcholine, the neurotransmitter of focus and muscle activation.
Improved vertical-jump peak power ~8.5% vs placebo; caffeine and placebo did not.
Double-blind crossover RCT · n=13 · 600 mg, 45 min pre — Parker et al., 2015 — J Int Soc Sports Nutr
Acute 600 mg improved measures of attention and processing speed in healthy adults vs placebo.
Double-blind crossover RCT · n=26 · 600 mg single dose — 2024 — Nutrients (cognition RCT)
Bottom line: Small human trials support a modest power-output bump (~8–14%) and a short-term focus effect at 600 mg — but the studies are tiny (a dozen-odd people each), so the evidence is far thinner than for creatine or caffeine.
Usually mild — headache or GI upset. One observational study linked high intake to stroke risk; the finding is debated and not established.
Anecdotes, not evidence, and not medical advice. Frequency labels are our read of forum sentiment, not a formal survey. Individual responses vary widely.
| Per serving | |
|---|---|
| Typical branded single-ingredient product | $0.75 |
| Bulk powder at the clinical dose (250g 50%, $33.97) | $0.16 |
Buying bulk powder instead of a branded bottle saves about 78% per serving.
Bulk price: $33.97/250g → Alt source: $24.99/250gEducational only — not medical advice. Grades and clinical doses are computed from public labels against sourced research (citations on the main site); prices last verified 2026-07-21. Expensive Powder has no sponsors; bulk links may earn an affiliate commission, which never affects a grade. Talk to a clinician before starting any supplement.