Source: Examine.com — Berberine — 500 mg 2–3×/day (~1,500 mg total) for glucose/lipid outcomes.
500 mg per dose, typically taken 2–3×/day (~1,500 mg total).
A plant alkaloid with metabolic effects that rival the drug metformin in some trials.
Activates AMPK, a master metabolic switch that improves how cells handle glucose and fat.
Commonly causes GI upset (cramping, diarrhea) — split into 500 mg doses with meals. Interacts with many medications (it inhibits CYP enzymes); avoid in pregnancy. Talk to a doctor if on any prescription.
| Per serving | |
|---|---|
| Typical branded single-ingredient product | $0.50 |
| Bulk powder at the clinical dose (250g, $54.97) | $0.11 |
Buying bulk powder instead of a branded bottle saves about 78% per serving.
Bulk price: $54.97/250g → Alt source: $18.99/125gEducational only — not medical advice. Grades and clinical doses are computed from public labels against sourced research (citations on the main site); prices last verified 2026-07-21. Expensive Powder has no sponsors; bulk links may earn an affiliate commission, which never affects a grade. Talk to a clinician before starting any supplement.